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While clinical trials show that these drugs share many common side effects, its important to note that each clinical trial is unique and conducted under varying conditions, with different sample sizes

Just a month after adamantly opposing dosing reductions at the 2009 advisory committee meeting, McNeil wrote top FDA officials, offering a plan that recognized the will of the advisory committee

Additional doses may be taken as well

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Tumor heterogeneity in GBM poses difficulties in understanding the benefits of autophagy-related treatments

In addition, the high costs of the preparation technology used and certain stability problems can create difficulties in the clinical expansion of these types of formulations [219,221]