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Environmental factors like diet are known modulators of the microbiota: for instance, a fiber-rich diet promotes bacteria that produce short-chain fatty acids (SCFAs) like butyrate, while a Western diet high in fats and red meats can encourage pro-inflammatory microbial populations

Secondary effects from IGF-1 therapy were reported after administration of doses higher than 6080 g/kg/day

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This could be justified by the fact that Clarithromycins inhibition of CYP3A4 might lower the turnover rate of the enzyme in the liver, leading to reduced CYP450 content per liver gram (Ji et al., 2024)