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Sakai D, Mochida J, Yamamoto Y, Nomura T, Okuma M, Nishimura K, Nakai T, Ando K, Hotta T: Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration

Completed human trials establishing safety and efficacy would enable consideration for approval pathways

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The reasons are specific and addressable when identified early in the protocol

A level that drops back into range supports intake was the cause

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