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In addition, that dihydromyricetin-induced ROS downregulation was demonstrated to activate caspase-9 and trigger PARP cleavage, leading to apoptotic cell death in human hepatoma HepG2 cells [50], and that the flavonoid dihydromyricetin reportedly induced apoptosis in Hepal-6 hepatoma cells by reducing ROS generation via the TGF-/Smad3 pathway [51]

UV exposure, pollution, smoking, and hormonal fluctuations can all contribute to collagen loss

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But as we wrote in the intro, the topic is complex and controversial so here are some of the questions that keep coming up around slathering EGF all over our face

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