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A study in aging monkeys evaluated Epithalons influence on melatonin secretion.(11) Reported effects: Epithalon appeared to normalize or increase melatonin levels back toward youthful patterns Suggested restoration of circadian rhythm amplitude This points to a possible pineal-supporting activity of Epithalon in models of age-related melatonin decline

Some animal trials suggest this peptide may enhance recovery following myocardial infarction, and in certain cases, DSIP like material may even reduce myocardial infarction occurrence when stress is a contributing factor

doi: 10.1038/s41582-021-00605-6

The experiments were performed in a buffer solution containing 20 mM HEPES (pH 7.0) and 150 mM NaCl