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The safety and tolerability profile of NAC is also an advantage

Proc Natl Acad Sci USA 86: 90159019
Anti-Inflammatory Properties of N-Acetylcysteine on Lipopolysaccharide-Activated Macrophages

Ascorbate interacts with glutathione (GSH), thioredoxin (Trx), CoQ10, -tocopherol, and retinol to considerably enhance the cellular antioxidant system in addition to suppressing the production of free radicals [166]

For example, the most frequent phenotype of CYP2D6 is extensive-metabolizer (78.8%)

Hence, enhancing mitophagy through diverse mechanisms offers promising new strategies to overcome drug resistance in PCa (Katreddy et al., 2018)