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In summary, these results show that HSMGSH metabolization by ADH5 can prevent cytoplasmic GSH:GSSG imbalance by regenerating cellular GSH
(2) cysteinyl-tRNA synthase (CARS), which stimulates ferroptosis through a transsulfuration pathway (27)
These peripheral clocks coordinate organ-specific functions, including glomerular filtration (Song et al., 2024), tubular reabsorption (Bignon et al., 2023), and electrolyte excretion (Costello et al., 2025) in the kidneys, as well as intraocular pressure (IOP) regulation (Ikegami et al., 2020), tear secretion (Huang et al., 2025), and photoreceptor maintenance in the eyes (Fagiani et al., 2022

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Physiol Rev 99(4):20152113
Rosario AM, Cruz PE, Ceballos-Diaz C, et al
