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Cuprizone is a copper chelator and considering that dysregulation of copper homeostasis in humans can lead to neurodegenerative diseases such as Menkes disease [86, 87], Wilsons diseases [88] and is thought to contribute to Alzheimers disease and Parkinsons disease [88, 89], better understanding potential mechanisms underlying demyelination mediated by copper chelation is necessary to better understand cuprizone toxicity

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