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A throughline between all these differences is an overwhelming dissatisfaction
The primary human hepatocytes and human fetal hepatocytes are more clinically and physiologically relevant
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They manifest no abnormalities in adulthood, live 15% longer than wt animals and are resistant to a high glucose diet (Figs 6a and 7a)
*Based on a clinical in-vivo efficacy study of 30 women, ages 45 and up, applied twice daily
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