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Keywords: vasoactive intestinal peptide, VIP, VPAC1, VPAC2, vasodilation, neuropeptide, gastrointestinal, gastrointestinal tract, gastrointestinal secretion, mast cells, gastrointestinal motility, colitis, functional bowel syndromes Introduction Vasoactive intestinal peptide (VIP) is a 28-residue amino acid peptide first characterized in 1970 that was initially isolated from porcine duodenum 1