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Although normal electron transport in mitochondria involves four-electron reduction of molecular oxygen to water, partial reduction reactions occur even under physiologic conditions, causing release of O 2 and hydrogen peroxide

FLDP-5 and FLDP-8, curcumin analogs featuring a piperidone structure, can induce LN-18 cell death in a concentration-dependent manner (IC50: FLDP-5 2.5 M
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[DOI] [PubMed] [Google Scholar] 385.Pei Y., Otieno D., Gu I., Lee S.O., Parks J.S., Schimmel K., Kang H.W