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Lands LC et al

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This is usually associated with high mortality and morbidity, mostly due to cardiovascular and/or respiratory diseases, renal failure, and elevated risk of multiple cancers especially colorectal cancer (274277)

[DOI] [PubMed] [Google Scholar] Hirose S, Mitsudome A, Yasumoto S, Ogawa A, Muta Y, Tomoda Y

Sporadic dosing, skipping doses frequently, or constantly changing protocols prevents achieving steady-state effects

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