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-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells

This confirms our previous finding of induction of \(\gamma\)-glutamyl cysteine ligase (GCLC) with another Nrf2 inducer, 18--glycyrrhetinic acid [71], contributing to the induction of mitochondrial catalase, HO-1, malic enzyme and glutathione handling (GST, thioredoxin reductase, GCLC)

This suggests that a high intake of saturated fats and animal protein may contribute to redox imbalance and the development of autoimmunity

10.3389/fcell.2015.00080 75 PiacentiniS.LA FraziaS.RiccioA.PedersenJ

Its a naturally occurring antioxidanta tripeptide made up of glutamine, cysteine, and glycine

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