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(2014) 9:e88201

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Manipulation of MSCs with growth factors, biological agents, hypoxia, and genetic engineering Manipulation and pre-activation of MSCs are strategic approaches designed to address the challenges encountered in stem cell therapy, such as poor transplantation outcomes, low survival rates, and limited efficacy under various host conditions, including age, disease, and immune response

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doi: 10.1038/nrn3617 38

Wang, X., Qiu, L., Li, Z., Wang, X.-Y