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indeed, myeloid-specific ablation of HO-1 in bone marrow-derived macrophages (BM-DMs) treated with either M1- (LPS) or M2- (IL-4) polarizing signals produced an increase in the expression of M1 markers (CXCL10, IL-1b, MCP1), along with the decrease of M2 markers (Arg1 and CD163) (61)

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