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These active forms do not require conversion by the liver, which is often burdened by chronic inflammation and oxidative stress

[DOI] [PubMed] [Google Scholar] Coller B.S., Springer K.T., Scudder L.E., Kutok J.L., Ceruso M., Prestwich G.D

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However, in 2022, a PD clinical trial with the iron chelator deferiprone showed that, despite effectively reducing brain iron levels, deferiprone was associated with worsening motor and nonmotor symptoms 209