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doi: 10.3390/cancers15051609 250 SpadeaMSaglioFTripodiSIMenconiMZeccaMFagioliF
Therapeutic targeting of ferroptosis holds great promise for mitigating ARDS severity

BOX 9-1 Erythrocyte Metabolic Processes Requiring Energy Intracellular cationic gradient maintenance Maintenance of membrane phospholipid distribution Maintenance of skeletal protein deformability Maintenance of functional hemoglobin with ferrous iron Protecting cell proteins from oxidative denaturation Glycolysis initiation and maintenance Glutathione synthesis Nucleotide salvage reactions Glucose enters the RBC without energy expenditure via the transmembrane protein Glut-1

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Most patients see improvements within 2 - 6 weeks
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