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Seemingly in opposition to the theory that the diminished GH secretion of older age is a net detriment are observations that animal models of congenital GH deficiency have remarkably increased lifespan, and that humans with congenital GH deficiency may have decreased rates of age-related diseases such as diabetes and cancer

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Some protein tags even improve the solubility of target proteins, making them easier to work with, or change other properties such as a proteins localization or degradation in cells