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However, these effects are dose-dependent and typically diminish over time (113)

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2024;7(11):e2444659

B12 may appear normal, but the transport mechanism may not be saturated and therefore, in the absence of dietary intake, transcobalamin may not be delivering the vitamin to the tissues (tissue deficiency), but blood values will continue to appear normal

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27 investigated five patients with clEDS and histological investigations reported gross abnormalities of the elastic fibers and microfibrils in the dermis of these patients and reduced dermal collagen content