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[DOI] [PubMed] [Google Scholar] Do KQ, Trabesinger AH, Kirsten-Krger M, Lauer CJ, Dydak U, Hell D, Holsboer F, Boesiger P, Cunod M

These investigations consistently indicate a lack of evidence supporting a causal relationship between elevated serum urate levels and the risk of developing type 2 diabetes mellitus, coronary heart disease, ischemic stroke, and heart failure

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It plays critical roles in DNA repair, gene expression, metabolism, and cell signaling, all of which are central to energy production and longevity

The 2-ketobutyrate is converted to propionyl-CoA via the addition of Co-A catalyzed via branched-chain keto acid dehydrogenase (BCKD)

Therefore, depression in COPD patients should not be viewed solely as a psychological distress but rather as a condition with potential inflammatory underpinnings