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Sigmoidal dose-response curves and reliable estimates of IC 50 values based on non-linear least-squares fitting to the available data could not be obtained since no significant inhibition of DNMT1 and PRMT3 was observed at the tested NNMT inhibitor concentrations (Table 3)

At research doses of 0.252mg daily, AHK-Cu delivers approximately 0.050.4mg elemental copper per day well below the tolerable upper intake level of 10mg daily established by the NIH

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