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Vitiligo is one of the most common hypomelanoses

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Most side effects are mild, localized, and transient

This exceptional selectivity profile enables researchers to attribute observed effects specifically to NNMT inhibition, rather than off-target activities that plague less specific compounds

Treatment includes controlling blood sugar, medications like duloxetine or pregabalin, and sometimes non-medication therapies to manage symptoms and prevent complications such as ulcers and infections