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[244] [245] Following the EUA issuance, BioNTech and Pfizer continued the Phase III clinical trial to finalize safety and efficacy data, leading to application for licensure (approval) of the vaccine in the United States

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The most dramatic increase is in the perimenopause population: as of February 2026, 1 in 20 women aged 4554 has an active estrogen-based HRT prescription, a 184% increase across the study period