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Description
W.CarsonA.P.et al (2020)
Kim HR, Lee A, Choi E J, et al
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In vivo , CHE significantly inhibited tumor growth in the SKOV3 xenograft model and further enhanced the ferroptosis effect by inhibiting the expression of Nrf2 and related antioxidant proteins (186)
Advances such as nucleoside modification and removal of double-stranded RNA contaminants have mitigated this issue, but even current mRNA-LNPs formulations can trigger reactogenic effects in a dose-dependent manner, and repeated dosing may be limited by immune reactions against delivery components (for instance, anti-polyethylene glycol (PEG) antibodies can form, since many LNPs incorporate PEGylated lipids) [2]
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