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developed active TP-encapsulating nanoreactors, which, due to their stability and lack of cytotoxicity and inflammatory response, could offer a more effective and safer enzyme replacement therapy option

The invention also encompasses polynucleotides that hybridize under stringent or lower stringency hybridization conditions, e.g., as defined supra, to polynucleotides that encode an antibody, preferably, that specifically binds to a polypeptide of the invention, preferably, an antibody that binds to a polypeptide having the amino acid sequence of SEQ ID NO:2

Further, iron chelators (DFO and CPX), glutaminolysis inhibitors Compound 968, and AOA can also inhibit erastin-induced ferroptosis (Figure 7CD), demonstrating that ferroptosis requires the cellular metabolic process glutaminolysis

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BUPHENYL may cause serious side effects, including: Nervous system side effects (Neurotoxicity) Phenylacetate (PAA), a breakdown product of BUPHENYL, may cause nervous system side effects

Weak signaling can keep repair cells from organizing new tissue