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In patients with diabetes and albuminuria, the HRs for MACE, HHF, and CKD progression with triple combination therapy were estimated to be 0.65 (95% CI 0.550.76), 0.45 (95% CI 0.340.58), and 0.42 (95% CI 0.310.56), respectively, compared with those for conventional therapy alone (renin-angiotensin system inhibitors and classical risk factor management)
PMID: 6328354

However, the results vary widely

10.3109/08977194.2011.582839 58 KrishnamoorthyB.KhanM

N., et al., Pulmonary Chemokine and Mutagenic Responses in Rats After Subchronic Inhalation of Amorphous and Crystalline Silica, Toxicological Sciences: An Official Journal of the Society of Toxicology 56 (2000): 405413

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