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The half-life of BPC-157 was reported to be less than 30 minutes, following linear phar- macokinetics, after single and repeat intramuscular and intravenous dose administration

doi: 10.1136/ard-2022-222852 9 LowesMASuarez-FarinasMKruegerJG

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Manufacturing, Purity, and Safety Concerns Why manufacturing matters BPC-157 is made using a complex chemical process involving: Synthetic amino acids (Fmoc-protected amino acids) Polymer resins (Rink, Wang, or PAL resin) Aggressive solvents (DMF, DCM) Reactive coupling agents (HATU, HBTU, DIC, PyBOP) Strong acids (TFA) HPLC chemicals and stabilizers In pharmaceutical-grade production, these chemicals are removed to trace levels through validated purification steps and quality control testing

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