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Obesity among children surged dramatically from 0.4 million (1990) to 12.5 million (2022)

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Interestingly, activation of these receptors can trigger intracellular signaling cascades

Dhindsa DS, Mehta A, Sandesara PB, et al

Around 1520 min after a meal, levels of GLP-1 and GIP in the blood rise and stimulate receptors on pancreatic cells, leading to a glucose-dependent insulin response to process carbohydrates and fats

Given the role of insulin, growth hormone, and sex steroids in pubertal maturation, pharmacological modulation of appetite and energy balance during this window may theoretically influence musculoskeletal development, bone mineralization, and long-term metabolic health