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doi: 10.1038/nri3863

Effects described are drawn from cited research in study subjects.

It stimulates pituitary release of endogenous GH, which can lead to downstream increases in insulin-like growth factor-1, or IGF-1

10.1007/s00213-019-05271-7 9 KarilaL.MarillierM.ChaumetteB.BillieuxJ.FranchittoN.BenyaminaA

Table of Contents How Retatrutide Affects Heart Rate Retatrutide increases resting heart rate primarily through GLP-1 receptor-mediated chronotropic effects at the sinoatrial node, potentially amplified by its glucagon receptor agonism, which independently raises heart rate and cardiac contractility
