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Chloramphenicol can interfere with blood response to B12 in some cases, and metformin or long-term acid reducers can contribute to low B12 status

Effects of the MTHFR Mutation: Reduced Folate Metabolism: Folate (vitamin B9) is essential for many processes in the body, and MTHFR mutations can hinder the conversion of folate to its active form (5-MTHF)

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Compound 47 exhibited the best IRAP inhibitory capacity (IC50 = 105 nM) and demonstrated an almost 10-fold selectivity vs