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Histone deacetylasemediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity

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Armbrecht U, Stockbrgger RW, Rode J, Menon GG

, IL-6, IL-1, TNF-, and PGE2 )and serum lipopolysaccharides levels [216,217,218,219,220] and disrupting the intestinal environment, including reducing the diversity of intestinal microorganisms [216, 217] and fecal SCFAs [216, 217, 221], and regulating intestinal PH value [221] and oxidative stress through glycoxidation (NO, protein carbonyl (PCO), MPO and alkaline phosphatase (ALP)) [220, 221]

50 & Target [2] In Vitro Isotretinoin (13-cis-Retinoic acid) may act as a pro-drug that is converted intracellularly to metabolites that are agonists for RAR and RXR nuclear receptors [1]

The researchers monitored animals twice daily