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NAMPT inhibition by FK866 is important, leading to NAD + depletion, which causes a reduction in glucose uptake, ATP production, fatty acid synthesis, an increase in ROS levels and affects the activity of all NAD + -dependent enzymes, such as sirtuins and PARPs

Sung et al., 2021)

While it can be obtained through food and supplements, not everyone can absorb adequate amounts through diet alone

Scandinavian Journal of Rehabilitation Medicine, 6 , 128133

Moreover, the anti-tumor effect of C3G in OS cells was also achieved mainly by inducing apoptosis rather than necrosis, and the effect varied depending on the OS cell type (159)