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Importantly, flow cytometric analysis of MZB both excluded any gene-dosage effect of Gclc expression and confirmed that loss of MZB was independent of any Cre -associated toxicity (Supplementary Fig

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(2) Synthesis of the isoprenoid tail: The isoprenoid tail of CoQ is synthesized through the cytosolic mevalonate pathway, which produces key precursors such as isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) 28,31