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Thiodepsipeptides can be synthesized in a similar manner, but instead of using Ser or Thr, Cys is incorporated

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Although it shows a protective effect against hypertension and kidney damage induced by RUPP rats when administered in late gestation, it exacerbates the preeclampsia-like phenotype when given in early gestation, predisposing to a smaller placenta and increasing proteinuria

Establishing unified and standardized OA animal models, local administration protocols, and comprehensive efficacy evaluation systems will be key to promoting the translation of ferroptosis-targeted therapies from the laboratory to the clinic