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The chemical reaction producing NO occurs thanks to the presence of amino acid L-arginine via nitric oxide synthase (NOS) activity and leads to final synthesis of L-citrulline and NO (Table 1)
These abnormalities impact airway contractility, cell proliferation, and calcium regulation, contributing to fibrosis, oxidative stress, and apoptosis [6467]
[DOI] [PMC free article] [PubMed] [Google Scholar] 198.Bode B.P., Fuchs B.C., Hurley B.P., Conroy J.L., Suetterlin J.E., Tanabe K.K., Rhoads D.B., Abcouwer S.F., Souba W.W
Rodriguez, L
PMID 11159911
Biochemistry 19, 1519 [DOI] [PubMed] [Google Scholar] 15
