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CrossRef Estimated glucose disposal rate predicts frailty through diabetes: Evidence from machine learning and mediation models in NHANES Wentao Yang, Qian Cheng, Guoxin Huang, Hongming Lin, Yee Gary Ang PLOS One.2025

CD8 + T cells exhibit higher infiltration levels in metastatic brain lesions than in primary brain tumors, such as gliomas [66], but most of these cells are in a functionally exhausted state, with increased expression of inhibitory receptors such as PD1 and TIM3 [67]

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By overcoming these challenges and advancing our understanding of DRs genetic and molecular underpinnings, gene therapy has the potential to revolutionize DR management, offering new hope for patients suffering from this debilitating disease ( 4.3 Individualized management using genetic information 4.3.1 Integration of genetic insights in clinical management Integrating genetic information into DR management heralds a transformative era of personalized medicine, offering new avenues for patients with this complication

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