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Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial media

Although single-cell transcriptional profiling shows substantial microglial heterogeneity across brain regions in PD, limited sample sizes currently restrict definitive conclusions [267]

Jayaram HN, Kusumanchi P, Yalowitz JA

A recent study employing expansion microscopy to examine the photoreceptor connecting cilium revealed that tubulin glutamylation and long-chain polyglutamylation are predominantly concentrated on the outer doublet MTs [62]

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Therefore, linker design should integrate PK/PD (pharmacokinetic/pharmacodynamic) data to optimize in vivo distribution and drug exposure