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5A peptide induces macrophages cholesterol efflux via ABCA1-mediated mechanism both in vivo and vitro, and reduces atherosclerosis in Apo E-absent mice 150

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This relative deficiency contributes to mitochondrial dysfunction, impaired substrate metabolism, and metabolic inflexibilitythe inability to efficiently switch between carbohydrate and fat oxidation based on substrate availability

Why it was included in the FDA ban Research on DSIP in humans is still lacking, per the FDA

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