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Specifically, 75.7% is bound to intact mitochondria or large extracellular vesicles (EVs), 18.4% is associated with small EVs, and 5.9% forms complexes with exosomes or protein structures

M., Sheng J

doi: 10.1016/j.jconrel.2020.09.024

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In GPX1 KO mouse bronchoalveolar lavage fluid, LPS-mediator levels and macrophage numbers were lower

Below, we summarize how each pathway contributes to IPF pathogenesis and highlight representative NPs that target these molecular mechanisms