glutathione paracetamol metabolism Toxicology of Poisoning – Pharm.D Aid PharmGKB summary: Pathways of acetaminophen

Eisner BH, Sheth S, Dretler SP, Herrick B, Pais VM, Jr

J Biol Chem 281:2174521754 Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, De Machado R, Leid M, McBurney MW, Guarente L (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

Springer (2012)

appetite suppression Naltrexone/bupropion (Contrave): Opioid antagonist + antidepressant

Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells

This can occur because you consume fewer calories, which means your body has less fuel to work with