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Mirpuri E, Garca-Trevijano ER, Castilla-Cortazar I, Berasain C, Quiroga J, Rodriguez-Ortigosa C, Mato JM, Prieto J, Avila MA

This represents a significant limitation in the evidence base, as large-scale human trials examining musculoskeletal applications have not been published

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However, a 2017 meta-analysis looking at almost 8,000 studies found only two brain training programs had more than one study in their favor (BrainHQ and CogniFit), and theres no evidence to support them as a preventative or treatment strategy.56 Ultimately, playing brain games wont make a huge difference in your cognition, but it can help you flex some skills better than another round of Candy Crush

This is relevant for the short-acting GLP-1 agonists, whereas tachyphylaxis rapidly develops for the long-acting agonists [8]

Important context: this is early data and should be interpreted cautiously