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But they come with significant drawbacks: high cost, injection site reactions, increased infection risk due to immune suppression, and the development of anti-drug antibodies over time that can reduce efficacy

Some of the most common thermo-responsive polymers used to prepare IN gel formulations include poloxamers (poloxamer 188 and poloxamer 407) and chitosan [26,27]

Regular sterile water is single-use once opened

Drugs for 'protein clouds': targeting intrinsically disordered transcription factors

A 2024 pilot study found that 7 of 12 patients with chronic knee pain reported relief lasting six or more months after BPC-157 treatment

It may also help protect against future injuries by strengthening these vital connective tissues