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Clinical Spectrum of Pigmented Oral Lesions Benign Lesions Physiologic (racial) pigmentation: symmetrical, diffuse, persistent Melanotic macule: well-circumscribed, small (less than 7 mm), uniform color Oral nevus: rare, usually asymptomatic, brown/blue-black Amalgam tattoo: bluish-gray macule associated with dental restorations Potentially Malignant or Malignant Lesions Oral melanoma: asymmetrical, irregular borders, color variegation Post-inflammatory pigmentation: variable presentation Drug-induced pigmentation: diffuse or localized depending on agent Recommended Article : Webinar Webinar: What are Oral Potentially Malignant Disorders

RNA-sequencing Murine brown adipocytes were treated with/without 4CBA (4 mM) for 24 h, and n = 3 independent biological replicates were pooled to generate total RNA samples

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Creel, and Glenn T

American Antiquity 70(1):144-156