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PLoS ONE 11:e0162318 Siegel R, Naishadham D, Jemal AA (2013) Analysis of fiducials implanted during EUS for patients with localized rectal cancer receiving high-dose rate endorectal brachytherapy

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VEGF, in addition to acting as a mitogenic signal for vascular endothelial cells, protects tumor vasculature from apoptosis by inducing anti-apoptotic factors, mediates the activation of extracellular matrix degrading enzymes, and promotes tumor-immune evasion by recruiting immunosuppressive cells such as Tregs, TAMs, and MDSCs

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