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Trials 15 , 115 (2014)

Increased mtROS generation may contribute to IR and drive the progression of NASH and MASLD [196, 197]

doi: 10.1136/bmjonc-2024-000535

Nature 421:384388

Interestingly, the decrease in sorbitol dehydrogenase (SDH), which plays a key role in the maturation of the germinal epithelial layer of the seminiferous tubule, combined with the increase in lactate dehydrogenase (LDH), supports the hypothesis of damage to the germinal epithelium (Alboghobeish et al., 2019)

It builds on the foundation laid by semaglutide and tirzepatide but adds the glucagon receptor component that may explain its superior weight loss outcomes