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While MOTS-C shows a favorable safety profile, longer use periods warrant careful finding

Nutrition and Metabolism, 7(1), 37-50

Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface

used the animal model of acatalasemic mice, which has less CAT activity as compared to control mice but no difference in GPx activity (Wang et al., 1996)

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Histone demethylation requires Jumonji C-domain-containing histone demethylases, which are also ascorbate-dependent 2-ODDs, thereby providing a further means for ascorbate to influence gene expression [129], [139]