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Nature (2000) 403(6765):415

Approximately 70% of the population experiences eye floaters or flashes in their lifetime

As with other amino-acid cofactor-containing enzymes, formation of the CDO Cys-Tyr cross-link required a transition metal cofactor [ferrous iron (Fe 2+ )] and oxygen (O 2 )], but unlike other amino-acid cofactor-containing enzymes, biogenesis of the CDO cross-link did not occur immediately upon exposure to metal and O 2, , was not essential for basal catalytic activity, and was strictly dependent upon the presence of its specific substrate Cys

[14] Clinical significance [edit] The GPx1 allele with five Ala repeats is significantly associated with breast cancer risk

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However, because it does not harm melanocytes, it is regarded as a non-cytotoxic depigmenting agent, making it safer than more aggressive lighteners like as hydroquinone (but not without risks)