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sc) did not improve renal outcomes in patients with acute renal failure, compared to placebo, after a mean period of 10 days.36 To account for co-founding factors in acute renal injury, recombinant IGF-1 administration was also tested in transplant patients receiving a cadaveric kidney allograft.37 In these patients, treatment with IGF-1 similarly failed to significantly improve renal function compared to placebo, suggesting that the regenerative effects of IGF-1 observed in animal models of renal ischemia may not be directly scalable to patients with acute renal failure

The thigh is also easy to reach, making it a preferred site for those who self-administer shots

In a phase 2 trial, once-weekly cagrilintide produced dose-dependent weight reductions in people with overweight or obesity, which is what moved the amylin pathway into serious combination development ( Lau et al., Lancet 2021 )