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[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Kathmann M., Flau K., Redmer A., Trankle C., Schlicker E

An integrative strategy should also incorporate in vivo selectivity assays, transcriptomic co-expression analyses, and disease-contextualized transporter profiling to ensure beneficial neuromodulatory effects while minimizing compensatory or deleterious responses

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Nanomedicine 14, 229253

While in-vitro studies supported the idea that n-acetylcysteine may be useful in the treatment of methemoglobinemia, a crossover, randomized trial on human volunteers with induced methemoglobinemia demonstrated that intravenous n-acetylcysteine offers no reduction in methemoglobin concentration in blood