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Siliphos (Silybin Phytosome ) Contains flavonoids known for their hepatoprotective effect

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Acknowledgements The research is supported by the National Key Research and Development Program of China (2020YFA0908200 and 2020YFA0710800), the Key Program of the National Natural Science Foundation of China (81930043 and 82330055), the National Natural Science Foundation of China (T2225003, 82001719, 52073060, and 61927805), the Natural Science Foundation of Jiangsu (BE2018707), the Nanjing Medical Science and Technique Development Foundation (ZKX21019) and the Clinical Trials from Nanjing Drum Tower Hospital (2022-LCYI-ZD-01)

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The context-dependent regulation of NRF2 creates therapeutic dilemmas: While NRF2 activation shows promise for treating neurodegenerative diseases by enhancing antioxidant defenses, its inhibition may be required in cancers where NRF2 hyperactivation promotes tumor survival and drug resistance

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